Apple CEO Tim Cook on Tuesday bashed federal antitrust efforts to lessen the App Store’s dominance of e-commerce, saying it would leave iPhone users more vulnerable to cyberattackers.

Apple is facing growing scrutiny from regulators and lawmakers who say Apple’s and Google’s requirements for app developers are anti-competitive. Mr. Cook said his policy opponents have good intentions but are misguided.

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Big Tech critic Matt Stoller, research director at the liberal American Economic Liberties Project, said in a series of Twitter posts that Mr. Cook’s privacy-centric argument is misleading.

“Apple tried to refuse unlocking an iPhone to help solve a shooting at a Navy base in Pensacola,” Mr. Stoller said in one tweet. “There was a court warrant, so this wasn’t some glorious stand on privacy.”